Royal Air Force Typhoon FGR4s have operated alongside France's air force in a coordinated attack against an hidden munitions depot in Syria employed by the IS group, as stated by the British defence ministry.
The facility, pinpointed through intelligence, was thought to be housing weapons and explosive materials, the release indicated, and was situated in mountainous terrain just to the north of Palmyra in the heart of Syria.
"The RAF jets utilized laser-guided Paveway IV weapons to hit a number of approach shafts leading to the site... initial indications are that the strike was effective," the MoD said.
There was no evidence of any harm to civilians in the strike conducted Saturday night and every plane involved made a safe return, the MoD added.
The Typhoon FGR4s were supported by a Voyager tanker plane.
The Islamic State group - referred to as the so-called Islamic State - imposed militant control over large swathes of Syria and Iraq prior to its 2019 collapse.
"This action demonstrates British leadership, and determination to stand shoulder to shoulder with our allies, to eradicate any resurgence of IS and their dangerous and violent ideologies in the region," UK Defence Secretary John Healey remarked.
RAF aircraft have carried out overwatch operations over Syria to "forestall any efforts to regroup" of Islamic State after its defeat at the climactic battle in Baghuz in 2019, the MoD reported.
"I extend gratitude to all the members of the UK armed forces participating in this mission for their skill and their valour," the Defence Secretary said. "Including them were thousands of British troops deployed over the festive period. This mission, to eliminate militants who endanger our security, shows how our armed forces are always on standby, continuously, ensuring Britain's security at home and strong abroad."
During December, the United States armed forces carried out what it called a "large-scale strike" targeting Islamic State objectives in Syria, after an attack killed two US servicemembers and a local interpreter in Palmyra.
The UN reports Islamic State still has an estimated 5,000 to 7,000 combatants in both countries.